Name:
Nonnenmacher and Hiller.pdf
Size:
1.958Mb
Format:
PDF
Description:
Open Access article
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2018-03-03
Metadata
Show full item recordAbstract
In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.Citation
Biochemistry of proinflammatory macrophage activation. 2018 Cell. Mol. Life Sci.Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.PubMed ID
29502308Type
ArticleLanguage
enISSN
1420-9071ae974a485f413a2113503eed53cd6c53
10.1007/s00018-018-2784-1
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
Related articles
- Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
- Authors: Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN
- Issue date: 2016 Jul 12
- Itaconate: an emerging determinant of inflammation in activated macrophages.
- Authors: Yu XH, Zhang DW, Zheng XL, Tang CK
- Issue date: 2019 Feb
- Itaconate: the poster child of metabolic reprogramming in macrophage function.
- Authors: O'Neill LAJ, Artyomov MN
- Issue date: 2019 May
- The role of itaconate in host defense and inflammation.
- Authors: Peace CG, O'Neill LA
- Issue date: 2022 Jan 18
- Metabolic features of macrophages in inflammatory diseases and cancer.
- Authors: Na YR, Je S, Seok SH
- Issue date: 2018 Jan 28