Biochemistry of proinflammatory macrophage activation.

Nonnenmacher, Yannic; Hiller, Karsten

dc.contributor.author	Nonnenmacher, Yannic
dc.contributor.author	Hiller, Karsten
dc.date.accessioned	2018-04-06T09:36:46Z
dc.date.available	2018-04-06T09:36:46Z
dc.date.issued	2018-03-03
dc.identifier.citation	Biochemistry of proinflammatory macrophage activation. 2018 Cell. Mol. Life Sci.	en
dc.identifier.issn	1420-9071
dc.identifier.pmid	29502308
dc.identifier.doi	10.1007/s00018-018-2784-1
dc.identifier.uri	http://hdl.handle.net/10033/621337
dc.description.abstract	In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Biochemistry of proinflammatory macrophage activation.	en
dc.type	Article	en
dc.contributor.department	Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Cellular and molecular life sciences : CMLS	en
refterms.dateFOA	2018-06-13T04:22:13Z
html.description.abstract	In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.