Elsinopirins A-D, Decalin Polyketides from the Ascomycete Elsinoё pyri.

Surup, Frank; Pommerehne, Kathrin; Schroers, Hans-Josef; Stadler, Marc

dc.contributor.author	Surup, Frank
dc.contributor.author	Pommerehne, Kathrin
dc.contributor.author	Schroers, Hans-Josef
dc.contributor.author	Stadler, Marc
dc.date.accessioned	2018-04-11T12:46:25Z
dc.date.available	2018-04-11T12:46:25Z
dc.date.issued	2018-02-05
dc.identifier.citation	Elsinopirins A-D, Decalin Polyketides from the Ascomycete Elsinoё pyri. 2018, 8 (1) Biomolecules	en
dc.identifier.issn	2218-273X
dc.identifier.pmid	29401753
dc.identifier.doi	10.3390/biom8010008
dc.identifier.uri	http://hdl.handle.net/10033/621345
dc.description.abstract	In course of our screening for new secondary metabolites from ecological niche specialized, phytopathogenic fungi, the plant pathogenElsinoё pyri, strain 2203C, was found to produce four novel compounds (1-4), which were named elsinopirins A-D, in addition to the known metabolite elsinochrome A (5). After isolation by preparative high-performance liquid chromatography (HPLC), their structures, including relative stereochemistry, were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. Finally, absolute stereochemistry was assigned by chemical shifts of Mosher's esters (α-methoxy-α-trifluoromethylphenylacetic acid; MTPA) derivatives of elsinopirin B (2). The compounds were found to be devoid of significant antibacterial, antifungal, and cytotoxic activities.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Elsinopirins A-D, Decalin Polyketides from the Ascomycete Elsinoё pyri.	en
dc.type	Article	en
dc.contributor.department	Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Biomolecules	en
refterms.dateFOA	2018-06-12T17:41:05Z
html.description.abstract	In course of our screening for new secondary metabolites from ecological niche specialized, phytopathogenic fungi, the plant pathogenElsinoё pyri, strain 2203C, was found to produce four novel compounds (1-4), which were named elsinopirins A-D, in addition to the known metabolite elsinochrome A (5). After isolation by preparative high-performance liquid chromatography (HPLC), their structures, including relative stereochemistry, were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. Finally, absolute stereochemistry was assigned by chemical shifts of Mosher's esters (α-methoxy-α-trifluoromethylphenylacetic acid; MTPA) derivatives of elsinopirin B (2). The compounds were found to be devoid of significant antibacterial, antifungal, and cytotoxic activities.