Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
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Authors
Kuhn, MaikeSühs, Kurt-Wolfram
Akmatov, Manas K
Klawonn, Frank
Wang, Junxi
Skripuletz, Thomas
Kaever, Volkhard
Stangel, Martin
Pessler, Frank
Issue Date
2018-01-17
Metadata
Show full item recordAbstract
Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.Citation
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. 2018, 15 (1):20 J NeuroinflammationAffiliation
TWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.Journal
Journal of neuroinflammationPubMed ID
29343258Type
ArticleLanguage
enISSN
1742-2094ae974a485f413a2113503eed53cd6c53
10.1186/s12974-017-1041-0
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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