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dc.contributor.authorKuhn, Maike
dc.contributor.authorSühs, Kurt-Wolfram
dc.contributor.authorAkmatov, Manas K
dc.contributor.authorKlawonn, Frank
dc.contributor.authorWang, Junxi
dc.contributor.authorSkripuletz, Thomas
dc.contributor.authorKaever, Volkhard
dc.contributor.authorStangel, Martin
dc.contributor.authorPessler, Frank
dc.date.accessioned2018-04-12T13:50:11Z
dc.date.available2018-04-12T13:50:11Z
dc.date.issued2018-01-17
dc.identifier.citationMass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. 2018, 15 (1):20 J Neuroinflammationen
dc.identifier.issn1742-2094
dc.identifier.pmid29343258
dc.identifier.doi10.1186/s12974-017-1041-0
dc.identifier.urihttp://hdl.handle.net/10033/621349
dc.description.abstractVaricella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalJournal of neuroinflammationen
refterms.dateFOA2018-06-12T22:25:01Z
html.description.abstractVaricella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.


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