Differential magnesium implant corrosion coat formation and contribution to bone bonding.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsRahim, Muhammad Imran
Mueller, Peter P
MetadataShow full item record
AbstractMagnesium alloys are presently under investigation as promising biodegradable implant materials with osteoconductive properties. To study the molecular mechanisms involved, the potential contribution of soluble magnesium corrosion products to the stimulation of osteoblastic cell differentiation was examined. However, no evidence for the stimulation of osteoblast differentiation could be obtained when cultured mesenchymal precursor cells were differentiated in the presence of metallic magnesium or in cell culture medium containing elevated magnesium ion levels. Similarly, in soft tissue no bone induction by metallic magnesium or by the corrosion product magnesium hydroxide could be observed in a mouse model. Motivated by the comparatively rapid accumulation solid corrosion products physicochemical processes were examined as an alternative mechanism to explain the stimulation of bone growth by magnesium-based implants. During exposure to physiological solutions a structured corrosion coat formed on magnesium whereby the elements calcium and phosphate were enriched in the outermost layer which could play a role in the established biocompatible behavior of magnesium implants. When magnesium pins were inserted into avital bones, corrosion lead to increases in the pull out force, suggesting that the expanding corrosion layer was interlocking with the surrounding bone. Since mechanical stress is a well-established inducer of bone growth, volume increases caused by the rapid accumulation of corrosion products and the resulting force development could be a key mechanism and provide an explanation for the observed stimulatory effects of magnesium-based implants in hard tissue. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 697-709, 2017.
CitationDifferential magnesium implant corrosion coat formation and contribution to bone bonding. 2017, 105 (3):697-709 J Biomed Mater Res A
AffiliationHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Phosphate conversion coating reduces the degradation rate and suppresses side effects of metallic magnesium implants in an animal model.
- Authors: Rahim MI, Tavares A, Evertz F, Kieke M, Seitz JM, Eifler R, Weizbauer A, Willbold E, Jürgen Maier H, Glasmacher B, Behrens P, Hauser H, Mueller PP
- Issue date: 2017 Aug
- Polydopamine mediated assembly of hydroxyapatite nanoparticles and bone morphogenetic protein-2 on magnesium alloys for enhanced corrosion resistance and bone regeneration.
- Authors: Jiang Y, Wang B, Jia Z, Lu X, Fang L, Wang K, Ren F
- Issue date: 2017 Oct
- The formation of an organic coat and the release of corrosion microparticles from metallic magnesium implants.
- Authors: Badar M, Lünsdorf H, Evertz F, Rahim MI, Glasmacher B, Hauser H, Mueller PP
- Issue date: 2013 Jul
- In vivo corrosion of four magnesium alloys and the associated bone response.
- Authors: Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, Windhagen H
- Issue date: 2005 Jun
- Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal.
- Authors: Willbold E, Kalla K, Bartsch I, Bobe K, Brauneis M, Remennik S, Shechtman D, Nellesen J, Tillmann W, Vogt C, Witte F
- Issue date: 2013 Nov