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    Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

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    Authors
    Neumann, Jens
    Henneberg, Sophie
    von Kenne, Susanne
    Nolte, Niklas
    Müller, Andreas J
    Schraven, Burkhart
    Görtler, Michael W
    Reymann, Klaus G
    Gunzer, Matthias
    Riek-Burchardt, Monika
    Issue Date
    2018
    
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    Abstract
    Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.
    Citation
    Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo. 2018, 13 (3):e0193970 PLoS ONE
    Affiliation
    Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
    Journal
    PloS one
    URI
    http://hdl.handle.net/10033/621371
    DOI
    10.1371/journal.pone.0193970
    PubMed ID
    29543836
    Type
    Article
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0193970
    Scopus Count
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