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dc.contributor.authorNeumann, Jens
dc.contributor.authorHenneberg, Sophie
dc.contributor.authorvon Kenne, Susanne
dc.contributor.authorNolte, Niklas
dc.contributor.authorMüller, Andreas J
dc.contributor.authorSchraven, Burkhart
dc.contributor.authorGörtler, Michael W
dc.contributor.authorReymann, Klaus G
dc.contributor.authorGunzer, Matthias
dc.contributor.authorRiek-Burchardt, Monika
dc.date.accessioned2018-05-14T14:34:02Z
dc.date.available2018-05-14T14:34:02Z
dc.date.issued2018
dc.identifier.citationBeware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo. 2018, 13 (3):e0193970 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid29543836
dc.identifier.doi10.1371/journal.pone.0193970
dc.identifier.urihttp://hdl.handle.net/10033/621371
dc.description.abstractInflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.
dc.language.isoenen
dc.titleBeware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPloS oneen
refterms.dateFOA2018-06-13T21:39:21Z
html.description.abstractInflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.


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