Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.

Schneider, Kai Markus; Wirtz, Theresa H; Kroy, Daniela; Albers, Stefanie; Neumann, Ulf Peter; Strowig, Till; Sellge, Gernot; Trautwein, Christian

dc.contributor.author	Schneider, Kai Markus
dc.contributor.author	Wirtz, Theresa H
dc.contributor.author	Kroy, Daniela
dc.contributor.author	Albers, Stefanie
dc.contributor.author	Neumann, Ulf Peter
dc.contributor.author	Strowig, Till
dc.contributor.author	Sellge, Gernot
dc.contributor.author	Trautwein, Christian
dc.date.accessioned	2018-05-18T11:41:56Z
dc.date.available	2018-05-18T11:41:56Z
dc.date.issued	2018-05-18
dc.identifier.citation	Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation., 12 (1):76-84 Case Rep Gastroenterol	en
dc.identifier.issn	1662-0631
dc.identifier.pmid	29606940
dc.identifier.doi	10.1159/000481937
dc.identifier.uri	http://hdl.handle.net/10033/621374
dc.description.abstract	Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.	en
dc.type	Article	en
dc.contributor.department	Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Case reports in gastroenterology	en
refterms.dateFOA	2018-06-13T00:27:22Z
html.description.abstract	Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.