Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC mice.

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Authors
Akeus, Paulina
Szeponik, Louis
Ahlmanner, Filip
Sundström, Patrik
Alsén, Samuel
Gustavsson, Bengt
Sparwasser, Tim cc
Raghavan, Sukanya
Quiding-Järbrink, Marianne
Issue Date
2018-04-18

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Abstract
Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC
Affiliation
TWINCORE, Zentrum für experimentelle uns klinische Ifektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
URI
http://hdl.handle.net/10033/621400
DOI
10.1007/s00262-018-2161-9
PubMed ID
29671006
Type
Article
ISSN
1432-0851
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Attribution-NonCommercial-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States