Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity.
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Authors
Strunz, BenediktHengst, Julia
Deterding, Katja
Manns, Michael P
Cornberg, Markus
Ljunggren, Hans-Gustaf
Wedemeyer, Heiner
Björkström, Niklas K
Issue Date
2018-06-11
Metadata
Show full item recordAbstract
Diversity is a central requirement for the immune system's capacity to adequately clear a variety of different infections. As such, natural killer (NK) cells represent a highly diverse population of innate lymphocytes important in the early response against viruses. Yet, the extent to which a chronic pathogen affects NK cell diversity is largely unknown. Here we study NK cell functional diversification in chronic hepatitis C virus (HCV) infection. High-dimensional flow cytometer assays combined with stochastic neighbor embedding analysis reveal that chronic HCV infection induces functional imprinting on human NK cells that is largely irreversible and persists long after successful interventional clearance of the virus. Furthermore, HCV infection increases inter-individual, but decreases intra-individual, NK cell diversity. Taken together, our results provide insights into how the history of infections affects human NK cell diversity.Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.PubMed ID
29891939Type
ArticleISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/s41467-018-04685-9
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States