Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013.
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Authors
Tappe, DennisSchlottau, Kore
Cadar, Daniel
Hoffmann, Bernd
Balke, Lorenz
Bewig, Burkhard
Hoffmann, Donata
Eisermann, Philip
Fickenscher, Helmut
Krumbholz, Andi
Laufs, Helmut
Huhndorf, Monika
Rosenthal, Maria
Schulz-Schaeffer, Walter
Ismer, Gabriele
Hotop, Sven-Kevin
Brönstrup, Mark

Ott, Anthonina
Schmidt-Chanasit, Jonas
Beer, Martin
Issue Date
2018-06-01
Metadata
Show full item recordAbstract
Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost's squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany. Molecular assays and immunohistochemistry detected a limbic distribution of the virus in brain tissue of the animal caretaker. Phylogenetic analyses demonstrated a spillover infection from the Prevost's squirrel. Antibodies against bornaviruses were detected in the patient's cerebrospinal fluid by immunofluorescence and newly developed ELISAs and immunoblot. The putative antigenic epitope was identified on the viral nucleoprotein. Other zoo workers were not infected; however, avoidance of direct contact with exotic squirrels and screening of squirrels are recommended.Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.PubMed ID
29774846Type
ArticleISSN
1080-6059ae974a485f413a2113503eed53cd6c53
10.3201/eid2406.172027
Scopus Count
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- Creative Commons
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