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dc.contributor.authorTappe, Dennis
dc.contributor.authorSchlottau, Kore
dc.contributor.authorCadar, Daniel
dc.contributor.authorHoffmann, Bernd
dc.contributor.authorBalke, Lorenz
dc.contributor.authorBewig, Burkhard
dc.contributor.authorHoffmann, Donata
dc.contributor.authorEisermann, Philip
dc.contributor.authorFickenscher, Helmut
dc.contributor.authorKrumbholz, Andi
dc.contributor.authorLaufs, Helmut
dc.contributor.authorHuhndorf, Monika
dc.contributor.authorRosenthal, Maria
dc.contributor.authorSchulz-Schaeffer, Walter
dc.contributor.authorIsmer, Gabriele
dc.contributor.authorHotop, Sven-Kevin
dc.contributor.authorBrönstrup, Mark
dc.contributor.authorOtt, Anthonina
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorBeer, Martin
dc.date.accessioned2018-07-04T10:58:35Z
dc.date.available2018-07-04T10:58:35Z
dc.date.issued2018-06-01
dc.identifier.issn1080-6059
dc.identifier.pmid29774846
dc.identifier.doi10.3201/eid2406.172027
dc.identifier.urihttp://hdl.handle.net/10033/621420
dc.description.abstractLimbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost's squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany. Molecular assays and immunohistochemistry detected a limbic distribution of the virus in brain tissue of the animal caretaker. Phylogenetic analyses demonstrated a spillover infection from the Prevost's squirrel. Antibodies against bornaviruses were detected in the patient's cerebrospinal fluid by immunofluorescence and newly developed ELISAs and immunoblot. The putative antigenic epitope was identified on the viral nucleoprotein. Other zoo workers were not infected; however, avoidance of direct contact with exotic squirrels and screening of squirrels are recommended.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectBornavirusen_US
dc.subjectGermanyen_US
dc.subjectVSBV-1en_US
dc.subjectlimbic encephalitisen_US
dc.subjectoccupational risken_US
dc.subjectsquirrelen_US
dc.subjecttransmissionen_US
dc.subjectvariegated squirrel bornavirus 1en_US
dc.subjectvirusesen_US
dc.subjectzoonosesen_US
dc.titleOccupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-07-04T10:58:35Z
dc.source.journaltitleEmerging infectious diseases


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