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dc.contributor.authorHeß, Nathalie
dc.contributor.authorWaldow, Franziska
dc.contributor.authorKohler, Thomas P
dc.contributor.authorRohde, Manfred
dc.contributor.authorKreikemeyer, Bernd
dc.contributor.authorGómez-Mejia, Alejandro
dc.contributor.authorHain, Torsten
dc.contributor.authorSchwudke, Dominik
dc.contributor.authorVollmer, Waldemar
dc.contributor.authorHammerschmidt, Sven
dc.contributor.authorGisch, Nicolas
dc.date.accessioned2018-08-08T13:17:51Z
dc.date.available2018-08-08T13:17:51Z
dc.date.issued2017-12-12
dc.identifier.issn2041-1723
dc.identifier.pmid29233962
dc.identifier.doi10.1038/s41467-017-01720-z
dc.identifier.urihttp://hdl.handle.net/10033/621443
dc.description.abstractTeichoic acid (TA), a crucial cell wall constituent of the pathobiont Streptococcus pneumoniae, is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA). Both TA polymers share a common precursor synthesis pathway, but differ in the final transfer of the TA chain to either peptidoglycan or a glycolipid. Here, we show that LTA exhibits a different linkage conformation compared to WTA, and identify TacL (previously known as RafX) as a putative lipoteichoic acid ligase required for LTA assembly. Pneumococcal mutants deficient in TacL lack LTA and show attenuated virulence in mouse models of acute pneumonia and systemic infections, although they grow normally in culture. Hence, LTA is important for S. pneumoniae to establish systemic infections, and TacL represents a potential target for antimicrobial drug development.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleLipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-08-08T13:17:51Z
dc.source.journaltitleNature communications


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