A Model for the Transient Subdiffusive Behavior of Particles in Mucus.

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Authors
Ernst, Matthias
John, Thomas
Guenther, Marco
Wagner, Christian
Schaefer, Ulrich F
Lehr, Claus-Michael
Issue Date
2017-01-10

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Abstract
In this study we have applied a model to explain the reported subdiffusion of particles in mucus, based on the measured mean squared displacements (MSD). The model considers Brownian diffusion of particles in a confined geometry, made from permeable membranes. The applied model predicts a normal diffusive behavior at very short and long time lags, as observed in several experiments. In between these timescales, we find that the "subdiffusive" regime is only a transient effect, MSD∝τ
Affiliation
HIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.
URI
http://hdl.handle.net/10033/621447
DOI
10.1016/j.bpj.2016.11.900
PubMed ID
28076809
Type
Article
Language
en
ISSN
1542-0086
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