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Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).

dc.contributor.authorEhrentraut, Stefan
dc.contributor.authorNagel, Stefan
dc.contributor.authorPommerenke, Claudia
dc.contributor.authorDirks, Wilhelm G
dc.contributor.authorQuentmeier, Hilmar
dc.contributor.authorKaufmann, Maren
dc.contributor.authorMeyer, Corinna
dc.contributor.authorZaborski, Margarete
dc.contributor.authorGeffers, Robert
dc.contributor.authorFujiwara, Hiroshi
dc.contributor.authorDrexler, Hans G
dc.contributor.authorMacLeod, Roderick A F
dc.date.accessioned2018-08-20T13:34:51Z
dc.date.available2018-08-20T13:34:51Z
dc.date.issued2017-01-01
dc.identifier.issn1592-8721
dc.identifier.pmid28659334
dc.identifier.doi10.3324/haematol.2017.168203
dc.identifier.urihttp://hdl.handle.net/10033/621450
dc.description.abstractFocal amplifications and chromosome translocations involving the long arm of chromosome 19 (19q13.3) are recurrent in T-cell lymphoma, where neighboring BCL3 and PVRL2 are competing target genes. Here we present the oncogenomic characterization of a peripheral T-cell lymphoma (PTCL) cell line T8ML-1 to reveal t(14;19)(q11.2;q13.3) juxtaposing TRA@ and PVRL2. Parallel mRNA and protein expression data for the 19q13.3 region of interest pinpointed PVRL2 as the sole conspicuous target therein. Collectively, our findings endorse T8ML-1 as the first proven cell line model for t(14;19)/PTCL.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titlePeripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-08-20T13:34:52Z
dc.source.journaltitleHaematologica


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