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dc.contributor.authorPetersen, Henning
dc.contributor.authorMostafa, Ahmed
dc.contributor.authorTantawy, Mohamed A
dc.contributor.authorIqbal, Azeem A
dc.contributor.authorHoffmann, Donata
dc.contributor.authorTallam, Aravind
dc.contributor.authorSelvakumar, Balachandar
dc.contributor.authorPessler, Frank
dc.contributor.authorBeer, Martin
dc.contributor.authorRautenschlein, Silke
dc.contributor.authorPleschka, Stephan
dc.date.accessioned2018-08-27T08:47:40Z
dc.date.available2018-08-27T08:47:40Z
dc.date.issued2018-01-01
dc.identifier.issn1664-302X
dc.identifier.pmid29623073
dc.identifier.doi10.3389/fmicb.2018.00526
dc.identifier.urihttp://hdl.handle.net/10033/621453
dc.description.abstractThe 2009 pandemic influenza A virus (IAV) H1N1 strain (H1N1pdm09) has widely spread and is circulating in humans and swine together with other human and avian IAVs. This fact raises the concern that reassortment between H1N1pdm09 and co-circulating viruses might lead to an increase of H1N1pdm09 pathogenicity in different susceptible host species. Herein, we explored the potential of different NS segments to enhance the replication dynamics, pathogenicity and host range of H1N1pdm09 strain A/Giessen/06/09 (Gi-wt). The NS segments were derived from (i) human H1N1- and H3N2 IAVs, (ii) highly pathogenic- (H5- or H7-subtypes) or (iii) low pathogenic avian influenza viruses (H7- or H9-subtypes). A significant increase of growth kinetics in A549 (human lung epithelia) and NPTr (porcine tracheal epithelia) cells was only noticeden_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectH1N1pdm09en_US
dc.subjectNS segmenten_US
dc.subjectinfluenza virusen_US
dc.subjectinnate immunityen_US
dc.subjectreassortmenten_US
dc.titleNS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2018-08-27T08:47:40Z
dc.source.journaltitleFrontiers in microbiology


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