Humanized mouse model supports development, function, and tissue residency of human natural killer cells.

Herndler-Brandstetter, Dietmar; Shan, Liang; Yao, Yi; Stecher, Carmen; Plajer, Valerie; Lietzenmayer, Melanie; Strowig, Till; de Zoete, Marcel R; Palm, Noah W; Chen, Jie; Blish, Catherine A; Frleta, Davor; Gurer, Cagan; Macdonald, Lynn E; Murphy, Andrew J; Yancopoulos, George D; Montgomery, Ruth R; Flavell, Richard A

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Issue Date

2017-11-07

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Abstract

Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (

Affiliation

Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.

Type

Article

ISSN

1091-6490

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publications of the research group microbial immunoregulation (MIKI)

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