Humanized mouse model supports development, function, and tissue residency of human natural killer cells.
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Herndler-Brandstetter et al.pdf
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Authors
Herndler-Brandstetter, DietmarShan, Liang
Yao, Yi
Stecher, Carmen
Plajer, Valerie
Lietzenmayer, Melanie
Strowig, Till

de Zoete, Marcel R
Palm, Noah W
Chen, Jie
Blish, Catherine A
Frleta, Davor
Gurer, Cagan
Macdonald, Lynn E
Murphy, Andrew J
Yancopoulos, George D
Montgomery, Ruth R
Flavell, Richard A
Issue Date
2017-11-07
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Show full item recordAbstract
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.PubMed ID
29078283Type
ArticleISSN
1091-6490ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1705301114
Scopus Count
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