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dc.contributor.authorHeck, Joachim G.
dc.contributor.authorRox, Katharina
dc.contributor.authorLünsdorf, Heinrich
dc.contributor.authorLückerath, Thorsten
dc.contributor.authorKlaassen, Nicole
dc.contributor.authorMedina, Eva
dc.contributor.authorGoldmann, Oliver
dc.contributor.authorFeldmann, Claus
dc.date.accessioned2018-09-26T12:17:08Z
dc.date.available2018-09-26T12:17:08Z
dc.identifier.issn2470-1343
dc.identifier.issn2470-1343
dc.identifier.doi10.1021/acsomega.8b00637
dc.identifier.urihttp://hdl.handle.net/10033/621497
dc.description.abstract[ZrO]2+[CLP]2– (CLP: clindamycinphosphate) inorganic–organic hybrid nanoparticles (IOH-NPs) represent a novel strategy to treat persisting, recurrent infections with multiresistant Staphylococcus aureus. [ZrO]2+[CLP]2– is prepared in water and contains the approved antibiotic with unprecedented high load (82 wt % CLP per nanoparticle). The IOH-NPs result in 70–150-times higher antibiotic concentrations at difficult-to-reach infection sites, offering new options for improved drug delivery for chronic and difficult-to-treat infections.en_US
dc.relation.urlhttp://pubs.acs.org/doi/10.1021/acsomega.8b00637en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleZirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persistingen_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
dc.source.volume3
dc.source.issue8
dc.source.beginpage8589
dc.source.endpage8594
refterms.dateFOA2018-09-26T12:17:09Z
dc.source.journaltitleACS Omega


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