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dc.contributor.authorBrandenberger, Christina
dc.contributor.authorKling, Katharina Maria
dc.contributor.authorVital, Marius
dc.contributor.authorChristian, Mühlfeld
dc.date.accessioned2018-10-05T08:42:30Z
dc.date.available2018-10-05T08:42:30Z
dc.date.issued2018-08-01
dc.identifier.issn2152-5250
dc.identifier.pmid30090646
dc.identifier.doi10.14336/AD.2017.0902
dc.identifier.urihttp://hdl.handle.net/10033/621507
dc.description.abstractAcute lung injury (ALI) is associated with increased morbidity and mortality in the elderly (> 65 years), but the knowledge about origin and effects of immunosenescence in ALI is limited. Here, we investigated the immune response at pulmonary, systemic and cellular level in young (2-3 months) and old (18-19 months) C57BL/6J mice to localize and characterize effects of immunosenescence in ALI. ALI was induced by intranasal lipopolysaccharide (LPS) application and the animals were sacrificed 24 or 72 h later. Pulmonary inflammation was investigated by analyzing histopathology, bronchoalveolar lavage fluid (BALF) cytometry and cytokine expression. Systemic serum cytokine expression, spleen lymphocyte populations and the gut microbiome were analyzed, as well as activation of alveolar and bone marrow derived macrophages (BMDM)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectacute lung injuryen_US
dc.subjectalveolar macrophagesen_US
dc.subjectimmunosenescenceen_US
dc.subjectlipopolysaccharideen_US
dc.subjectpulmonary inflammationen_US
dc.subjectsystemic inflammationen_US
dc.titleThe Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury.en_US
dc.typeArticleen_US
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-10-05T08:42:31Z
dc.source.journaltitleAging and disease


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