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dc.contributor.authorNiederstrasser, Julia
dc.contributor.authorHerr, Christian
dc.contributor.authorWolf, Lisa
dc.contributor.authorLehr, Claus M
dc.contributor.authorBeisswenger, Christoph
dc.contributor.authorBals, Robert
dc.date.accessioned2018-10-11T12:59:12Z
dc.date.available2018-10-11T12:59:12Z
dc.date.issued2016-11-01
dc.identifier.issn1098-5522
dc.identifier.pmid27400722
dc.identifier.doi10.1128/IAI.00282-16
dc.identifier.urihttp://hdl.handle.net/10033/621514
dc.description.abstractVitamin D (VitD) has a role in the regulation of calcium and phosphate metabolism and in addition impacts the activity of the immune system. VitD deficiency might be linked to increased susceptibility to respiratory tract infection. The aim of the present study was to characterize the impact of VitD deficiency on the susceptibility to bacterial infection in murine models. C57BL/6N mice were fed a diet with or without VitD for 10 weeks. The VitD-deficient or -sufficient mice were infected with Pseudomonas aeruginosa or Streptococcus pneumoniae The colonization and inflammatory response in the lung were analyzed at defined time points. The serum 25-hydroxy-VitD concentration was significantly lower in mice on the VitD-deficient diet. In infection experiments with Pseudomonas aeruginosa or Streptococcus pneumoniae, no differences could be observed in the numbers of viable bacteria or in differential cell counts in the bronchoalveolar lavage fluids. Measurements of inflammatory cytokines (KC and interleukin-1β [IL-1β]) did not show significant differences between the groups. In conclusion, VitD-deficient animals did not show significantly increased susceptibility to infection or an altered course of infection. The immune systems of humans and mice likely respond differently to VitD. Murine models are likely not appropriate for drawing conclusions on the role of VitD in human pulmonary host defense.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleVitamin D Deficiency Does Not Result in a Breach of Host Defense in Murine Models of Pneumonia.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.en_US
refterms.dateFOA2018-10-11T12:59:13Z
dc.source.journaltitleInfection and immunity


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