The olfactory epithelium as a port of entry in neonatal neurolisteriosis.
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Authors
Pägelow, DennisChhatbar, Chintan
Beineke, Andreas
Liu, Xiaokun
Nerlich, Andreas
van Vorst, Kira
Rohde, M

Kalinke, Ulrich

Förster, Reinhold
Halle, Stephan
Valentin-Weigand, Peter
Hornef, Mathias W
Fulde, Marcus
Issue Date
2018-10-15
Metadata
Show full item recordAbstract
Bacterial infections of the central nervous system (CNS) remain a major cause of mortality in the neonatal population. Commonly used parenteral infection models, however, do not reflect the early course of the disease leaving this critical step of the pathogenesis largely unexplored. Here, we analyzed nasal exposure of 1-day-old newborn mice to Listeria monocytogenes (Lm). We found that nasal, but not intragastric administration, led to early CNS infection in neonate mice. In particular, upon bacterial invasion of the olfactory epithelium, Lm subsequently spread along the sensory neurons entering the brain tissue at the cribriform plate and causing a significant influx of monocytes and neutrophils. CNS infection required listeriolysin for penetration of the olfactory epithelium and ActA, a mediator of intracellular mobility, for translocation into the brain tissue. Taken together, we propose an alternative port of entry and route of infection for neonatal neurolisteriosis and present a novel infection model to mimic the clinical features of late-onset disease in human neonates.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.PubMed ID
30323282Type
ArticleISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/s41467-018-06668-2
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States
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