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dc.contributor.authorPägelow, Dennis
dc.contributor.authorChhatbar, Chintan
dc.contributor.authorBeineke, Andreas
dc.contributor.authorLiu, Xiaokun
dc.contributor.authorNerlich, Andreas
dc.contributor.authorvan Vorst, Kira
dc.contributor.authorRohde, M
dc.contributor.authorKalinke, Ulrich
dc.contributor.authorFörster, Reinhold
dc.contributor.authorHalle, Stephan
dc.contributor.authorValentin-Weigand, Peter
dc.contributor.authorHornef, Mathias W
dc.contributor.authorFulde, Marcus
dc.date.accessioned2018-11-02T10:37:11Z
dc.date.available2018-11-02T10:37:11Z
dc.date.issued2018-10-15
dc.identifier.issn2041-1723
dc.identifier.pmid30323282
dc.identifier.doi10.1038/s41467-018-06668-2
dc.identifier.urihttp://hdl.handle.net/10033/621531
dc.description.abstractBacterial infections of the central nervous system (CNS) remain a major cause of mortality in the neonatal population. Commonly used parenteral infection models, however, do not reflect the early course of the disease leaving this critical step of the pathogenesis largely unexplored. Here, we analyzed nasal exposure of 1-day-old newborn mice to Listeria monocytogenes (Lm). We found that nasal, but not intragastric administration, led to early CNS infection in neonate mice. In particular, upon bacterial invasion of the olfactory epithelium, Lm subsequently spread along the sensory neurons entering the brain tissue at the cribriform plate and causing a significant influx of monocytes and neutrophils. CNS infection required listeriolysin for penetration of the olfactory epithelium and ActA, a mediator of intracellular mobility, for translocation into the brain tissue. Taken together, we propose an alternative port of entry and route of infection for neonatal neurolisteriosis and present a novel infection model to mimic the clinical features of late-onset disease in human neonates.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleThe olfactory epithelium as a port of entry in neonatal neurolisteriosis.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2018-11-02T10:37:12Z
dc.source.journaltitleNature communications


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