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dc.contributor.authorCalvert, Matthew B
dc.contributor.authorJumde, Varsha R
dc.contributor.authorTitz, Alexander
dc.date.accessioned2018-11-02T11:37:03Z
dc.date.available2018-11-02T11:37:03Z
dc.identifier.citationIPS, Helmholtz-Institut füt Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.issn1860-5397
dc.identifier.doi10.3762/bjoc.14.239
dc.identifier.urihttp://hdl.handle.net/10033/621532
dc.description.abstractThe rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes of anti-infectives must urgently be developed. Antibiotics with new modes of action are needed, but other concepts are also currently being pursued. Targeting bacterial virulence as a means of blocking pathogenicity is a promising new strategy for disarming pathogens. Furthermore, it is believed that this new approach is less susceptible towards resistance development. In this review, recent examples of anti-infective compounds acting on several types of bacterial targets, e.g., adhesins, toxins and bacterial communication, are described.en_US
dc.relation.urlhttps://www.beilstein-journals.org/bjoc/articles/14/239en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subject.meshantimicrobial resistanceen_US
dc.subject.meshbacterial adhesinsen_US
dc.subject.meshbacterial toxinsen_US
dc.subject.meshpathoblockersen_US
dc.subject.meshquorum sensingen_US
dc.titlePathoblockers or antivirulence drugs as a new option for the treatment of bacterial infectionsen_US
dc.typeArticleen_US
dc.source.volume14
dc.source.beginpage2607
dc.source.endpage2617
refterms.dateFOA2018-11-02T11:37:03Z
dc.source.journaltitleBeilstein Journal of Organic Chemistry


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