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Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers.

dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorBinder, Sebastian C
dc.contributor.authorMesin, Luka
dc.contributor.authorVictora, Gabriel D
dc.date.accessioned2018-11-02T12:06:40Z
dc.date.available2018-11-02T12:06:40Z
dc.date.issued2018-01-01
dc.identifier.issn1664-3224
dc.identifier.pmid30319600
dc.identifier.doi10.3389/fimmu.2018.02020
dc.identifier.urihttp://hdl.handle.net/10033/621534
dc.description.abstractClonal evolution of B cells in germinal centers (GCs) is central to affinity maturation of antibodies in response to pathogens. Permanent or tamoxifen-induced multi-color recombination of B cells based on the brainbow allele allows monitoring the degree of color dominance in the course of the GC reaction. Here, we use computer simulations of GC reactions in order to replicate the evolution of color dominanceen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectbrainbowen_US
dc.subjectclonal selectionen_US
dc.subjectcomputer simulationen_US
dc.subjectgerminal centeren_US
dc.subjectmathematical modelingen_US
dc.subjectmultiphoton imagingen_US
dc.subjectsequencingen_US
dc.titleComputer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers.en_US
dc.typeArticleen_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
refterms.dateFOA2018-11-02T12:06:41Z
dc.source.journaltitleFrontiers in immunology


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