RNA Structure-A Neglected Puppet Master for the Evolution of Virus and Host Immunity.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances in next generation sequencing technology, bioinformatics, and non-coding RNA biology have highlighted the many important roles of RNA in virtually every biological process. Our understanding of RNA biology has been further enriched by a number of significant advances in probing RNA structures. It is now appreciated that many cellular and viral biological processes are highly dependent on specific RNA structures and/or sequences, and such reliance will undoubtedly impact on the evolution of both hosts and viruses. As a contribution to this special issue on host immunity and virus evolution, it is timely to consider how RNA sequences and structures could directly influence the co-evolution between hosts and viruses. In this manuscript, we begin by stating some of the basic principles of RNA structures, followed by describing some of the critical RNA structures in both viruses and hosts. More importantly, we highlight a number of available new tools to predict and to evaluate novel RNA structures, pointing out some of the limitations readers should be aware of in their own analyses.
AffiliationHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States
- Paleovirology and virally derived immunity.
- Authors: Aswad A, Katzourakis A
- Issue date: 2012 Nov
- Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections.
- Authors: Lythgoe KA, Gardner A, Pybus OG, Grove J
- Issue date: 2017 May
- RNA-based mechanisms regulating host-virus interactions.
- Authors: Zhou R, Rana TM
- Issue date: 2013 May
- Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity.
- Authors: Leung P, Eltahla AA, Lloyd AR, Bull RA, Luciani F
- Issue date: 2017 Jul 15
- Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review.
- Authors: Dzananovic E, McKenna SA, Patel TR
- Issue date: 2018 Apr