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dc.contributor.authorSmyth, Redmond P
dc.contributor.authorNegroni, Matteo
dc.contributor.authorLever, Andrew M
dc.contributor.authorMak, Johnson
dc.contributor.authorKenyon, Julia C
dc.date.accessioned2018-11-05T14:31:57Z
dc.date.available2018-11-05T14:31:57Z
dc.date.issued2018-01-01
dc.identifier.issn1664-3224
dc.identifier.pmid30283444
dc.identifier.doi10.3389/fimmu.2018.02097
dc.identifier.urihttp://hdl.handle.net/10033/621536
dc.description.abstractThe central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances in next generation sequencing technology, bioinformatics, and non-coding RNA biology have highlighted the many important roles of RNA in virtually every biological process. Our understanding of RNA biology has been further enriched by a number of significant advances in probing RNA structures. It is now appreciated that many cellular and viral biological processes are highly dependent on specific RNA structures and/or sequences, and such reliance will undoubtedly impact on the evolution of both hosts and viruses. As a contribution to this special issue on host immunity and virus evolution, it is timely to consider how RNA sequences and structures could directly influence the co-evolution between hosts and viruses. In this manuscript, we begin by stating some of the basic principles of RNA structures, followed by describing some of the critical RNA structures in both viruses and hosts. More importantly, we highlight a number of available new tools to predict and to evaluate novel RNA structures, pointing out some of the limitations readers should be aware of in their own analyses.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectRNA structureen_US
dc.subjectimmune evasionen_US
dc.subjectsecondary structureen_US
dc.subjectviral RNAen_US
dc.subjectviral evolutionen_US
dc.titleRNA Structure-A Neglected Puppet Master for the Evolution of Virus and Host Immunity.en_US
dc.typeArticleen_US
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
refterms.dateFOA2018-11-05T14:31:57Z
dc.source.journaltitleFrontiers in immunology


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