Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.
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Authors
Chhatbar, ChintanDetje, Claudia N
Grabski, Elena
Borst, Katharina
Spanier, Julia
Ghita, Luca
Elliott, David A
Jordão, Marta Joana Costa
Mueller, Nora
Sutton, James
Prajeeth, Chittappen K
Gudi, Viktoria
Klein, Michael A
Prinz, Marco
Bradke, Frank
Stangel, Martin
Kalinke, Ulrich

Issue Date
2018-10-02
Metadata
Show full item recordAbstract
In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumulation of microglia are regulated by type I IFN receptor signaling of neurons and astrocytes, but not of microglia. Morphological analysis of myeloid cells shows that type I IFN receptor signaling of neurons has a stronger impact on the activation of myeloid cells than of astrocytes. Thus, in the infected CNS, the cross talk among neurons, astrocytes, and microglia is critical for full microglia activation and protection from lethal encephalitis.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.PubMed ID
30282022Type
ArticleISSN
2211-1247ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2018.09.003
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States
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