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dc.contributor.authorChhatbar, Chintan
dc.contributor.authorDetje, Claudia N
dc.contributor.authorGrabski, Elena
dc.contributor.authorBorst, Katharina
dc.contributor.authorSpanier, Julia
dc.contributor.authorGhita, Luca
dc.contributor.authorElliott, David A
dc.contributor.authorJordão, Marta Joana Costa
dc.contributor.authorMueller, Nora
dc.contributor.authorSutton, James
dc.contributor.authorPrajeeth, Chittappen K
dc.contributor.authorGudi, Viktoria
dc.contributor.authorKlein, Michael A
dc.contributor.authorPrinz, Marco
dc.contributor.authorBradke, Frank
dc.contributor.authorStangel, Martin
dc.contributor.authorKalinke, Ulrich
dc.date.accessioned2018-11-06T15:12:45Z
dc.date.available2018-11-06T15:12:45Z
dc.date.issued2018-10-02
dc.identifier.issn2211-1247
dc.identifier.pmid30282022
dc.identifier.doi10.1016/j.celrep.2018.09.003
dc.identifier.urihttp://hdl.handle.net/10033/621541
dc.description.abstractIn sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumulation of microglia are regulated by type I IFN receptor signaling of neurons and astrocytes, but not of microglia. Morphological analysis of myeloid cells shows that type I IFN receptor signaling of neurons has a stronger impact on the activation of myeloid cells than of astrocytes. Thus, in the infected CNS, the cross talk among neurons, astrocytes, and microglia is critical for full microglia activation and protection from lethal encephalitis.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectastrocytesen_US
dc.subjectencephalitisen_US
dc.subjectneuronsen_US
dc.subjectregulation of microglia activationen_US
dc.subjecttype I IFN receptor signalingen_US
dc.titleType I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2018-11-06T15:12:46Z
dc.source.journaltitleCell reports


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