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dc.contributor.authorMeiser, Johannes
dc.contributor.authorKraemer, Lisa
dc.contributor.authorJaeger, Christian
dc.contributor.authorMadry, Henning
dc.contributor.authorLink, Andreas
dc.contributor.authorLepper, Philipp M
dc.contributor.authorHiller, Karsten
dc.contributor.authorSchneider, Jochen G
dc.date.accessioned2018-11-08T13:10:12Z
dc.date.available2018-11-08T13:10:12Z
dc.date.issued2018-08-14
dc.identifier.issn1949-2553
dc.identifier.pmid30181801
dc.identifier.doi10.18632/oncotarget.25956
dc.identifier.urihttp://hdl.handle.net/10033/621545
dc.description.abstractItaconic acid is produced by mammalian leukocytes upon pro-inflammatory activation. It appears to inhibit bacterial growth and to rewire the metabolism of the host cell by inhibiting succinate dehydrogenase. Yet, it is unknown whether itaconic acid acts only intracellularly, locally in a paracrine fashion, or whether it is even secreted from the inflammatory cells at meaningful levels in peripheral blood of patients with severe inflammation or sepsis. The aim of this study was to determine the release rate of itaconic acid from pro-inflammatory activated macrophagesen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectImmunologyen_US
dc.subjectbiomarkeren_US
dc.subjectinflammationen_US
dc.subjectitaconic aciden_US
dc.subjectmetabolismen_US
dc.subjectsepsisen_US
dc.titleItaconic acid indicates cellular but not systemic immune system activation.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-11-08T13:10:13Z
dc.source.journaltitleOncotarget


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