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dc.contributor.authorKindt, Alida
dc.contributor.authorLiebisch, Gerhard
dc.contributor.authorClavel, Thomas
dc.contributor.authorHaller, Dirk
dc.contributor.authorHörmannsperger, Gabriele
dc.contributor.authorYoon, Hongsup
dc.contributor.authorKolmeder, Daniela
dc.contributor.authorSigruener, Alexander
dc.contributor.authorKrautbauer, Sabrina
dc.contributor.authorSeeliger, Claudine
dc.contributor.authorGanzha, Alexandra
dc.contributor.authorSchweizer, Sabine
dc.contributor.authorMorisset, Rosalie
dc.contributor.authorStrowig, Till
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorHelm, Dominic
dc.contributor.authorKüster, Bernhard
dc.contributor.authorKrumsiek, Jan
dc.contributor.authorEcker, Josef
dc.date.accessioned2018-11-08T14:08:56Z
dc.date.available2018-11-08T14:08:56Z
dc.date.issued2018-09-14
dc.identifier.issn2041-1723
dc.identifier.pmid30218046
dc.identifier.doi10.1038/s41467-018-05767-4
dc.identifier.urihttp://hdl.handle.net/10033/621546
dc.description.abstractInteractions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles. A composite classification score calculated from the observed alterations in fatty acid profiles in germfree mice clearly differentiates antibiotic-treated mice from untreated controls with high sensitivity. Mechanistic investigations reveal that acetate originating from gut microbial degradation of dietary fiber serves as precursor for hepatic synthesis of C16 and C18 fatty acids and their related glycerophospholipid species that are also released into the circulation.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleThe gut microbiota promotes hepatic fatty acid desaturation and elongation in mice.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-11-08T14:08:57Z
dc.source.journaltitleNature communications


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