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dc.contributor.authorSandargo, Birthe
dc.contributor.authorThongbai, Benjarong
dc.contributor.authorPraditya, Dimas
dc.contributor.authorSteinmann, Eike
dc.contributor.authorStadler, Marc
dc.contributor.authorSurup, Frank
dc.date.accessioned2018-11-12T09:10:37Z
dc.date.available2018-11-12T09:10:37Z
dc.date.issued2018-10-19
dc.identifier.issn1420-3049
dc.identifier.pmid30347707
dc.identifier.doi10.3390/molecules23102697
dc.identifier.urihttp://hdl.handle.net/10033/621553
dc.description.abstract4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectBasidiomycotaen_US
dc.subjectHCVen_US
dc.subjectHohenbuehelia griseaen_US
dc.subjectPleurotinen_US
dc.subjectfungien_US
dc.subjectsecondary metabolitesen_US
dc.subjectstructure elucidationen_US
dc.titleAntiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete .en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany; TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2018-11-12T09:10:37Z
dc.source.journaltitleMolecules (Basel, Switzerland)


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