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Tuberculosis is transmitted by inhalation of Mycobacterium tuberculosis-containing aerosols; 75 % of all patients show pulmonary manifestation. Immune responses after exposure that lead to clinical symptoms occur mainly in the respiratory tract and are only poorly understood. In most cases, cells of the innate immune system are believed to control the growth of or eradicate inhaled mycobacteria. However, this cannot be verified in vivo using standard methods. Subsequently, CD4+ and CD8+ T cell-driven adaptive immune responses are induced that attempt to control bacterial growth. The humoral defence appears to be less important. This article gives an overview of the current understanding of pulmonary immune mechanisms during exposure, latent infection, active disease and therapy of tuberculosis. Übersicht Herzmann C et al. Pulmonale Immunität bei … Pneumologie HAdditional Links
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-122961Type
ArticleISSN
0934-83871438-8790
ae974a485f413a2113503eed53cd6c53
10.1055/s-0043-122961
Scopus Count
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