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dc.contributor.authorSalah, Mohamed
dc.contributor.authorAbdelsamie, Ahmed S
dc.contributor.authorFrotscher, Martin
dc.date.accessioned2018-11-15T14:23:17Z
dc.date.available2018-11-15T14:23:17Z
dc.date.issued2018-10-15
dc.identifier.issn1872-8057
dc.identifier.pmid30336189
dc.identifier.doi10.1016/j.mce.2018.10.001
dc.identifier.urihttp://hdl.handle.net/10033/621569
dc.description.abstractDuring the past 25 years, the modulation of estrogen action by inhibition of 17β-hydroxysteroid dehydrogenase types 1 and 2 (17β-HSD1 and 17β-HSD2), respectively, has been pursued intensively. In the search for novel treatment options for estrogen-dependent diseases (EDD) and in order to explore estrogenic signaling pathways, a large number of steroidal and nonsteroidal inhibitors of these enzymes has been described in the literature. The present review gives a survey on the development of inhibitor classes as well as the structural formulas and biological properties of their most interesting representatives. In addition, rationally designed dual inhibitors of both 17β-HSD1 and steroid sulfatase (STS) as well as the first inhibitors of 17β-HSD14 are covered.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectEnzyme inhibitorsen_US
dc.subjectEstrogen dependent diseasesen_US
dc.subjectHydroxysteroid dehydrogenasesen_US
dc.subjectSteroidogenic enzymesen_US
dc.titleInhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut füt Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
atmire.accessrights
dc.source.journaltitleMolecular and cellular endocrinology


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