Nuclear lncRNA stabilization in the host response to bacterial infection.
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Issue Date
2018-07-02
Metadata
Show full item recordAbstract
Long non-coding RNAs (lncRNAs) play important roles in many cellular pathways, but their contribution to the defense of eukaryotic cells against pathogens remains poorly understood. A new study from Imamura et al in The EMBO Journal reports that Salmonella infection in human cells impacts nuclear RNA decay, which in turn drives the accumulation of otherwise unstable nuclear lncRNAs, some of which may have protective effects against this common bacterial pathogen. These unexpected findings demand more efforts to fully decrypt the molecular functions of lncRNAs in innate and adaptive immunity.Affiliation
HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.PubMed ID
29934294Type
ArticleISSN
1460-2075ae974a485f413a2113503eed53cd6c53
10.15252/embj.201899875
Scopus Count
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States