Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.

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Authors
Kurhade, Chaitanya
Schreier, Sarah
Lee, Yi-Ping
Zegenhagen, Loreen
Hjertqvist, Marika
Dobler, Gerhard
Kröger, Andrea cc
Överby, Anna K
Issue Date
2018-09-01

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Abstract
We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
URI
http://hdl.handle.net/10033/621578
DOI
10.3201/eid2409.171825
PubMed ID
30124404
Type
Article
ISSN
1080-6059
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Attribution-NonCommercial-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States