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dc.contributor.authorPhukhamsakda, Chayanard
dc.contributor.authorMacabeo, Allan Patrick G
dc.contributor.authorYuyama, Kamila Tomoko
dc.contributor.authorHyde, Kevin David
dc.contributor.authorStadler, Marc
dc.date.accessioned2018-12-03T15:06:11Z
dc.date.available2018-12-03T15:06:11Z
dc.date.issued2018-08-30
dc.identifier.issn1420-3049
dc.identifier.pmid30200229
dc.identifier.doi10.3390/molecules23092190
dc.identifier.urihttp://hdl.handle.net/10033/621598
dc.description.abstractRoussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp. (MFLUCC 17-2059), which represents an undescribed species, was isolated from Clematis subumbellata Kurz, fermented in yeast-malt medium and explored for its secondary metabolite production. Bioassay-guided fractionation of the crude extract yielded the new abscisic acid derivative, roussoellenic acid (1), along with pestabacillin B (2), a related congener, and the cyclodipeptide, cyclo(S-Pro-S-Ile) (3). The structure of 1 was determined by 2D NMR spectroscopy and HR-ESIMS data analysis. Compounds 1 and 2 showed inhibitory activity on biofilm formation by Staphylococcus aureus. The biofilm formation of S. aureus was reduced to 34% at 16 µg/mL by roussoellenic acid (1), while pestabacillin B (2) only showed 36% inhibition at 256 µg/mL. In addition, compound 1 also had weak cytotoxic effects on L929 murine fibroblasts and human KB3-1 cancer cells.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAnti-biofilmen_US
dc.subjectAscomycotaen_US
dc.subjectPleosporalesen_US
dc.subjectstructure elucidationen_US
dc.titleBiofilm Inhibitory Abscisic Acid Derivatives from the Plant-Associated Dothideomycete Fungus, sp.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-12-03T15:06:11Z
dc.source.journaltitleMolecules (Basel, Switzerland)


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