Show simple item record

dc.contributor.authorDudeck, Anne
dc.contributor.authorKöberle, Martin
dc.contributor.authorGoldmann, Oliver
dc.contributor.authorMeyer, Nicole
dc.contributor.authorDudeck, Jan
dc.contributor.authorLemmens, Stefanie
dc.contributor.authorRohde, M
dc.contributor.authorRoldán, Nestor González
dc.contributor.authorDietze-Schwonberg, Kirsten
dc.contributor.authorOrinska, Zane
dc.contributor.authorMedina, Eva
dc.contributor.authorHendrix, Sven
dc.contributor.authorMetz, Martin
dc.contributor.authorZenclussen, Ana Claudia
dc.contributor.authorvon Stebut, Esther
dc.contributor.authorBiedermann, Tilo
dc.date.accessioned2018-12-04T12:53:14Z
dc.date.available2018-12-04T12:53:14Z
dc.date.issued2018-11-20
dc.identifier.issn1097-6825
dc.identifier.pmid30468774
dc.identifier.doi10.1016/j.jaci.2018.10.054
dc.identifier.urihttp://hdl.handle.net/10033/621600
dc.description.abstractMast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs like skin or gut. MC can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focusses on the beneficial effects of mast cells on tissue homeostasis and elimination of toxins or venoms. MC can enhance pathogen clearance in many bacterial, viral, and parasite infections, e.g. by TLR2 triggered degranulation, secretion of antimicrobial cathelicidins, recruiting neutrophils or by providing extracellular DNA traps. The role of MC in tumors is more ambiguous, however, encouraging new findings show they can change the tumor microenvironment towards anti-tumor immunity when adequately triggered. Uterine tissue remodeling by α-chymase (MCP-5) is crucial for successful embryo implantation. MCP-4 and the tryptase MCP-6 emerge to be protective in CNS trauma by reducing inflammatory damage and excessive scar formation, thereby protecting axon growth. Last but not least, we see proteases like carboxypeptidase A released by FcεRI activated MC detoxify an increasing number of venoms and endogenous toxins. A better understanding of the plasticity of MC will help to improve these advantageous effects, and hint on ways to cut down detrimental MC actions.en_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCNS traumaen_US
dc.subjectinfectionen_US
dc.subjectinnate immunityen_US
dc.subjectmast cellen_US
dc.subjectmast cell proteaseen_US
dc.subjectpregnancyen_US
dc.subjecttoxinen_US
dc.subjecttumoren_US
dc.subjectvenomen_US
dc.titleMast cells as protectors of health.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.; HIPS, Helmholtz-Institut füt Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
refterms.dateFOA2018-12-04T12:53:14Z
dc.source.journaltitleThe Journal of allergy and clinical immunology


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Dudeck et al.pdf
Size:
3.190Mb
Format:
PDF
Description:
Open Access article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International