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dc.contributor.authorKnittel, Vanessa
dc.contributor.authorVollmer, Ines
dc.contributor.authorVolk, Marcel
dc.contributor.authorDersch, Petra
dc.date.accessioned2018-12-05T13:16:22Z
dc.date.available2018-12-05T13:16:22Z
dc.date.issued2018-01-01
dc.identifier.issn2235-2988
dc.identifier.pmid30460205
dc.identifier.doi10.3389/fcimb.2018.00378
dc.identifier.urihttp://hdl.handle.net/10033/621603
dc.description.abstractThe genus Yersinia includes three human pathogenic species, Yersinia pestis, the causative agent of the bubonic and pneumonic plague, and enteric pathogens Y. enterocolitica and Y. pseudotuberculosis that cause a number of gut-associated diseases. Over the past years a large repertoire of RNA-based regulatory systems has been discovered in these pathogens using different RNA-seq based approaches. Among them are several conserved or species-specific RNA-binding proteins, regulatory and sensory RNAs as well as various RNA-degrading enzymes. Many of them were shown to control the expression of important virulence-relevant factors and have a very strong impact on Yersinia virulence. The precise targets, the molecular mechanism and their role for Yersinia pathogenicity is only known for a small subset of identified genus- or species-specific RNA-based control elements. However, the ongoing development of new RNA-seq based methods and data analysis methods to investigate the synthesis, composition, translation, decay, and modification of RNAs in the bacterial cell will help us to generate a more comprehensive view of Yersinia RNA biology in the near futureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCsr/Rsm systemen_US
dc.subjectRNA processingen_US
dc.subjectRNA stabilityen_US
dc.subjectRNA thermometeren_US
dc.subjectgene regulationen_US
dc.subjectsmall regulatory RNAsen_US
dc.subjectvirulenceen_US
dc.titleDiscovering RNA-Based Regulatory Systems for Virulence.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2018-12-05T13:16:22Z
dc.source.journaltitleFrontiers in cellular and infection microbiology


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International