Discovering RNA-Based Regulatory Systems for Virulence.
dc.contributor.author | Knittel, Vanessa | |
dc.contributor.author | Vollmer, Ines | |
dc.contributor.author | Volk, Marcel | |
dc.contributor.author | Dersch, Petra | |
dc.date.accessioned | 2018-12-05T13:16:22Z | |
dc.date.available | 2018-12-05T13:16:22Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.issn | 2235-2988 | |
dc.identifier.pmid | 30460205 | |
dc.identifier.doi | 10.3389/fcimb.2018.00378 | |
dc.identifier.uri | http://hdl.handle.net/10033/621603 | |
dc.description.abstract | The genus Yersinia includes three human pathogenic species, Yersinia pestis, the causative agent of the bubonic and pneumonic plague, and enteric pathogens Y. enterocolitica and Y. pseudotuberculosis that cause a number of gut-associated diseases. Over the past years a large repertoire of RNA-based regulatory systems has been discovered in these pathogens using different RNA-seq based approaches. Among them are several conserved or species-specific RNA-binding proteins, regulatory and sensory RNAs as well as various RNA-degrading enzymes. Many of them were shown to control the expression of important virulence-relevant factors and have a very strong impact on Yersinia virulence. The precise targets, the molecular mechanism and their role for Yersinia pathogenicity is only known for a small subset of identified genus- or species-specific RNA-based control elements. However, the ongoing development of new RNA-seq based methods and data analysis methods to investigate the synthesis, composition, translation, decay, and modification of RNAs in the bacterial cell will help us to generate a more comprehensive view of Yersinia RNA biology in the near future | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Csr/Rsm system | en_US |
dc.subject | RNA processing | en_US |
dc.subject | RNA stability | en_US |
dc.subject | RNA thermometer | en_US |
dc.subject | gene regulation | en_US |
dc.subject | small regulatory RNAs | en_US |
dc.subject | virulence | en_US |
dc.title | Discovering RNA-Based Regulatory Systems for Virulence. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
refterms.dateFOA | 2018-12-05T13:16:22Z | |
dc.source.journaltitle | Frontiers in cellular and infection microbiology |