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dc.contributor.authorGemperlein, Katja
dc.contributor.authorZaburannyi, Nestor
dc.contributor.authorGarcia, Ronald
dc.contributor.authorLa Clair, James J
dc.contributor.authorMüller, Rolf
dc.date.accessioned2018-12-05T13:34:49Z
dc.date.available2018-12-05T13:34:49Z
dc.date.issued2018-09-05
dc.identifier.issn1660-3397
dc.identifier.pmid30189599
dc.identifier.doi10.3390/md16090314
dc.identifier.urihttp://hdl.handle.net/10033/621605
dc.description.abstractPrior to 2005, the vast majority of characterized myxobacteria were obtained from terrestrial habitats. Since then, several species of halotolerant and even obligate marine myxobacteria have been described. Chemical analyses of extracts from these organisms have confirmed their ability to produce secondary metabolites with unique chemical scaffolds. Indeed, new genera of marine-derived myxobacteria, particularly Enhygromyxa, have been shown to produce novel chemical scaffolds that differ from those observed in soil myxobacteria. Further studies have shown that marine sponges and terrestrial myxobacteria are capable of producing similar or even identical secondary metabolites, suggesting that myxobacterial symbionts may have been the true producers. Recent in silico analysis of the genome sequences available from six marine myxobacteria disclosed a remarkably versatile biosynthetic potential. With access to ever-advancing tools for small molecule and genetic evaluation, these studies suggest a bright future for expeditions into this yet untapped resource for secondary metabolitesen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbiosynthesisen_US
dc.subjectdiversityen_US
dc.subjectgenomicsen_US
dc.subjectmarine myxobacteriaen_US
dc.subjectnatural productsen_US
dc.subjectsecondary metabolismen_US
dc.titleMetabolic and Biosynthetic Diversity in Marine Myxobacteria.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
refterms.dateFOA2018-12-05T13:34:49Z
dc.source.journaltitleMarine drugs


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