Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.

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Authors
Vogel, Katrin
Pierau, Mandy
Arra, Aditya
Lampe, Karen
Schlueter, Dirk
Arens, Christoph
Brunner-Weinzierl, Monika C
Issue Date
2018-11-15

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Abstract
The origin of human T-cell responses against fungal pathogens early in life is not clearly understood. Here, we show that antifungal T-cell responses are vigorously initiated within the first years of life against lysates and peptides of Candida albicans or Aspergillus fumigatus, presented by autologous monocytes. The neonatal responding T-cell pool consists of 20 different TCR-V
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
Nature publishing group
URI
http://hdl.handle.net/10033/621621
DOI
10.1038/s41598-018-35161-5
PubMed ID
30442915
Type
Article
ISSN
2045-2322
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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International