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dc.contributor.authorZimmermann, Tina
dc.contributor.authorMaroso, Mattia
dc.contributor.authorBeer, Annika
dc.contributor.authorBaddenhausen, Sarah
dc.contributor.authorLudewig, Susann
dc.contributor.authorFan, Wenqiang
dc.contributor.authorVennin, Constance
dc.contributor.authorLoch, Sebastian
dc.contributor.authorBerninger, Benedikt
dc.contributor.authorHofmann, Clementine
dc.contributor.authorKorte, Martin
dc.contributor.authorSoltesz, Ivan
dc.contributor.authorLutz, Beat
dc.contributor.authorLeschik, Julia
dc.date.accessioned2018-12-19T13:46:39Z
dc.date.available2018-12-19T13:46:39Z
dc.date.issued2018-10-11
dc.identifier.issn1460-2199
dc.identifier.pmid30307491
dc.identifier.doi10.1093/cercor/bhy258
dc.identifier.urihttp://hdl.handle.net/10033/621622
dc.description.abstractNeural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses still remains elusive. NSCs contain a functional endocannabinoid system, including the cannabinoid type-1 receptor (CB1). To decipher whether CB1 regulates adult neurogenesis directly or indirectly in vivo, we performed NSC-specific conditional inactivation of CB1 by using triple-transgenic mice. Here, we show that lack of CB1 in NSCs is sufficient to decrease proliferation of the stem cell pool, which consequently leads to a reduction in the number of newborn neurons. Furthermore, neuronal differentiation was compromised at the level of dendritic maturation pointing towards a postsynaptic role of CB1 in vivo. Deteriorated neurogenesis in NSC-specific CB1 knock-outs additionally resulted in reduced long-term potentiation in the hippocampal formation. The observed cellular and physiological alterations led to decreased short-term spatial memory and increased depression-like behavior. These results demonstrate that CB1 expressed in NSCs and their progeny controls neurogenesis in adult mice to regulate the NSC stem cell pool, dendritic morphology, activity-dependent plasticity, and behavior.en_US
dc.publisherOxford University Publishingen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleNeural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.pmcidPMC6215469
refterms.dateFOA2018-12-19T13:46:39Z
dc.source.journaltitleCerebral cortex (New York, N.Y. : 1991)


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