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dc.contributor.authorHaque, A K M Ashiqul
dc.contributor.authorDewerth, Alexander
dc.contributor.authorAntony, Justin S
dc.contributor.authorRiethmüller, Joachim
dc.contributor.authorSchweizer, Georg R
dc.contributor.authorWeinmann, Petra
dc.contributor.authorLatifi, Ngadhnjim
dc.contributor.authorYasar, Hanzey
dc.contributor.authorPedemonte, Nicoletta
dc.contributor.authorSondo, Elvira
dc.contributor.authorWeidensee, Brian
dc.contributor.authorRalhan, Anjali
dc.contributor.authorLaval, Julie
dc.contributor.authorSchlegel, Patrick
dc.contributor.authorSeitz, Christian
dc.contributor.authorLoretz, Brigitta
dc.contributor.authorLehr, Claus-Michael
dc.contributor.authorHandgretinger, Rupert
dc.contributor.authorKormann, Michael S D
dc.date.accessioned2018-12-19T14:51:50Z
dc.date.available2018-12-19T14:51:50Z
dc.date.issued2018-11-13
dc.identifier.issn2045-2322
dc.identifier.pmid30425265
dc.identifier.doi10.1038/s41598-018-34960-0
dc.identifier.urihttp://hdl.handle.net/10033/621624
dc.description.abstractGene therapy has always been a promising therapeutic approach for Cystic Fibrosis (CF). However, numerous trials using DNA or viral vectors encoding the correct protein resulted in a general low efficacy. In the last years, chemically modified messenger RNA (cmRNA) has been proven to be a highly potent, pulmonary drug. Consequently, we first explored the expression, function and immunogenicity of human (h)CFTR encoded by cmRNAen_US
dc.publisherNature publishing groupen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleChemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut füt Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
refterms.dateFOA2018-12-19T14:51:50Z
dc.source.journaltitleScientific reports


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