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dc.contributor.authorMartinez Hernandez, Ana
dc.contributor.authorUrbanke, Hendrik
dc.contributor.authorGillman, Alan L
dc.contributor.authorLee, Joon
dc.contributor.authorRyazanov, Sergey
dc.contributor.authorAgbemenyah, Hope Y
dc.contributor.authorBenito, Eva
dc.contributor.authorJain, Gaurav
dc.contributor.authorKaurani, Lalit
dc.contributor.authorGrigorian, Gayane
dc.contributor.authorLeonov, Andrei
dc.contributor.authorRezaei-Ghaleh, Nasrollah
dc.contributor.authorWilken, Petra
dc.contributor.authorArce, Fernando Teran
dc.contributor.authorWagner, Jens
dc.contributor.authorFuhrmann, Martin
dc.contributor.authorCaruana, Mario
dc.contributor.authorCamilleri, Angelique
dc.contributor.authorVassallo, Neville
dc.contributor.authorZweckstetter, Markus
dc.contributor.authorBenz, Roland
dc.contributor.authorGiese, Armin
dc.contributor.authorSchneider, Anja
dc.contributor.authorKorte, Martin
dc.contributor.authorLal, Ratnesh
dc.contributor.authorGriesinger, Christian
dc.contributor.authorEichele, Gregor
dc.contributor.authorFischer, Andre
dc.date.accessioned2019-01-03T13:39:01Z
dc.date.available2019-01-03T13:39:01Z
dc.date.issued2018-01-01
dc.identifier.issn1757-4684
dc.identifier.pmid29208638
dc.identifier.doi10.15252/emmm.201707825
dc.identifier.urihttp://hdl.handle.net/10033/621628
dc.description.abstractAlzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further.en_US
dc.language.isoenen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAlzheimer's diseaseen_US
dc.subjectAβ channelsen_US
dc.subjectamyloid pathologyen_US
dc.subjectgene expressionen_US
dc.subjectmembrane poresen_US
dc.titleThe diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.en_US
dc.typeArticleen_US
refterms.dateFOA2019-01-03T13:39:02Z
dc.source.journaltitleEMBO molecular medicine


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