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dc.contributor.authorUllah, Sami
dc.contributor.authorSeidel, Katja
dc.contributor.authorTürkkan, Sibel
dc.contributor.authorWarwas, Dawid Peter
dc.contributor.authorDubich, Tatyana
dc.contributor.authorRohde, Manfred
dc.contributor.authorHauser, Hansjörg
dc.contributor.authorBehrens, Peter
dc.contributor.authorKirschning, Andreas
dc.contributor.authorKöster, Mario
dc.contributor.authorWirth, Dagmar
dc.date.accessioned2019-01-04T12:26:50Z
dc.date.available2019-01-04T12:26:50Z
dc.date.issued2018-12-23
dc.identifier.issn1873-4995
dc.identifier.pmid30586597
dc.identifier.doi10.1016/j.jconrel.2018.12.040
dc.identifier.urihttp://hdl.handle.net/10033/621629
dc.description.abstractTargeted delivery of drugs is a major challenge in treatment of diverse diseases. Systemically administered drugs demand high doses and are accompanied by poor selectivity and side effects on non-target cells. Here, we introduce a new principle for targeted drug delivery. It is based on macrophages as transporters for nanoparticle-coupled drugs as well as controlled release of drugs by hyperthermia mediated disruption of the cargo cells and simultaneous deliberation of nanoparticle-linked drugs. Hyperthermia is induced by an alternating electromagnetic field (AMF) that induces heat from silica-coated superparamagnetic iron oxide nanoparticles (SPIONs). We show proof-of-principle of controlled release by the simultaneous disruption of the cargo cells and the controlled, AMF induced release of a toxin, which was covalently linked to silica-coated SPIONs via a thermo-sensitive linker. Cells that had not been loaded with SPIONs remain unaffected. Moreover, in a 3D co-culture model we demonstrate specific killing of associated tumour cells when employing a ratio as low as 1:40 (SPION-loaded macrophage: tumour cells). Overall, our results demonstrate that AMF induced drug release from macrophage-entrapped nanoparticles is tightly controlled and may be an attractive novel strategy for targeted drug release.en_US
dc.language.isoenen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCell based drug deliveryen_US
dc.subjectControlled drug delivery, 3D tumour modelen_US
dc.subjectHyperthermiaen_US
dc.subjectMacrophagesen_US
dc.subjectMagnetic silica nanoparticlesen_US
dc.titleMacrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.source.journaltitleJournal of controlled release : official journal of the Controlled Release Society


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