Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model.
dc.contributor.author | Ullah, Sami | |
dc.contributor.author | Seidel, Katja | |
dc.contributor.author | Türkkan, Sibel | |
dc.contributor.author | Warwas, Dawid Peter | |
dc.contributor.author | Dubich, Tatyana | |
dc.contributor.author | Rohde, Manfred | |
dc.contributor.author | Hauser, Hansjörg | |
dc.contributor.author | Behrens, Peter | |
dc.contributor.author | Kirschning, Andreas | |
dc.contributor.author | Köster, Mario | |
dc.contributor.author | Wirth, Dagmar | |
dc.date.accessioned | 2019-01-04T12:26:50Z | |
dc.date.available | 2019-01-04T12:26:50Z | |
dc.date.issued | 2018-12-23 | |
dc.identifier.issn | 1873-4995 | |
dc.identifier.pmid | 30586597 | |
dc.identifier.doi | 10.1016/j.jconrel.2018.12.040 | |
dc.identifier.uri | http://hdl.handle.net/10033/621629 | |
dc.description.abstract | Targeted delivery of drugs is a major challenge in treatment of diverse diseases. Systemically administered drugs demand high doses and are accompanied by poor selectivity and side effects on non-target cells. Here, we introduce a new principle for targeted drug delivery. It is based on macrophages as transporters for nanoparticle-coupled drugs as well as controlled release of drugs by hyperthermia mediated disruption of the cargo cells and simultaneous deliberation of nanoparticle-linked drugs. Hyperthermia is induced by an alternating electromagnetic field (AMF) that induces heat from silica-coated superparamagnetic iron oxide nanoparticles (SPIONs). We show proof-of-principle of controlled release by the simultaneous disruption of the cargo cells and the controlled, AMF induced release of a toxin, which was covalently linked to silica-coated SPIONs via a thermo-sensitive linker. Cells that had not been loaded with SPIONs remain unaffected. Moreover, in a 3D co-culture model we demonstrate specific killing of associated tumour cells when employing a ratio as low as 1:40 (SPION-loaded macrophage: tumour cells). Overall, our results demonstrate that AMF induced drug release from macrophage-entrapped nanoparticles is tightly controlled and may be an attractive novel strategy for targeted drug release. | en_US |
dc.language.iso | en | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Cell based drug delivery | en_US |
dc.subject | Controlled drug delivery, 3D tumour model | en_US |
dc.subject | Hyperthermia | en_US |
dc.subject | Macrophages | en_US |
dc.subject | Magnetic silica nanoparticles | en_US |
dc.title | Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.source.journaltitle | Journal of controlled release : official journal of the Controlled Release Society |