High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
dc.contributor.author | Velázquez-Avila, Martha | |
dc.contributor.author | Balandrán, Juan Carlos | |
dc.contributor.author | Ramírez-Ramírez, Dalia | |
dc.contributor.author | Velázquez-Avila, Mirella | |
dc.contributor.author | Sandoval, Antonio | |
dc.contributor.author | Felipe-López, Alfonso | |
dc.contributor.author | Nava, Porfirio | |
dc.contributor.author | Alvarado-Moreno, José Antonio | |
dc.contributor.author | Dozal, David | |
dc.contributor.author | Prieto-Chávez, Jessica L | |
dc.contributor.author | Schaks, Matthias | |
dc.contributor.author | Rottner, Klemens | |
dc.contributor.author | Dorantes-Acosta, Elisa | |
dc.contributor.author | López-Martínez, Briceida | |
dc.contributor.author | Schnoor, Michael | |
dc.contributor.author | Pelayo, Rosana | |
dc.date.accessioned | 2019-01-04T14:15:01Z | |
dc.date.available | 2019-01-04T14:15:01Z | |
dc.date.issued | 2018-12-20 | |
dc.identifier.issn | 1476-5551 | |
dc.identifier.pmid | 30573781 | |
dc.identifier.doi | 10.1038/s41375-018-0333-4 | |
dc.identifier.uri | http://hdl.handle.net/10033/621631 | |
dc.description.abstract | Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leukemia (B-ALL) being the most frequent childhood malignancy. Relapse, treatment failure and organ infiltration worsen the prognosis, warranting a better understanding of the implicated mechanisms. Cortactin is an actin-binding protein involved in cell adhesion and migration that is overexpressed in many solid tumors and in adult B-cell chronic lymphocytic leukemia. Here, we investigated cortactin expression and potential impact on infiltration and disease prognosis in childhood B-ALL. B-ALL cell lines and precursor cells from bone marrow (BM) and cerebrospinal fluid (CSF) of B-ALL patients indeed overexpressed cortactin. In CXCL12-induced transendothelial migration assays, transmigrated B-ALL cells had highest cortactin expression. In xenotransplantation models, only cortactin | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature publishing group | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
refterms.dateFOA | 2019-01-04T14:15:02Z | |
dc.source.journaltitle | Leukemia |