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dc.contributor.authorVelázquez-Avila, Martha
dc.contributor.authorBalandrán, Juan Carlos
dc.contributor.authorRamírez-Ramírez, Dalia
dc.contributor.authorVelázquez-Avila, Mirella
dc.contributor.authorSandoval, Antonio
dc.contributor.authorFelipe-López, Alfonso
dc.contributor.authorNava, Porfirio
dc.contributor.authorAlvarado-Moreno, José Antonio
dc.contributor.authorDozal, David
dc.contributor.authorPrieto-Chávez, Jessica L
dc.contributor.authorSchaks, Matthias
dc.contributor.authorRottner, Klemens
dc.contributor.authorDorantes-Acosta, Elisa
dc.contributor.authorLópez-Martínez, Briceida
dc.contributor.authorSchnoor, Michael
dc.contributor.authorPelayo, Rosana
dc.date.accessioned2019-01-04T14:15:01Z
dc.date.available2019-01-04T14:15:01Z
dc.date.issued2018-12-20
dc.identifier.issn1476-5551
dc.identifier.pmid30573781
dc.identifier.doi10.1038/s41375-018-0333-4
dc.identifier.urihttp://hdl.handle.net/10033/621631
dc.description.abstractCancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leukemia (B-ALL) being the most frequent childhood malignancy. Relapse, treatment failure and organ infiltration worsen the prognosis, warranting a better understanding of the implicated mechanisms. Cortactin is an actin-binding protein involved in cell adhesion and migration that is overexpressed in many solid tumors and in adult B-cell chronic lymphocytic leukemia. Here, we investigated cortactin expression and potential impact on infiltration and disease prognosis in childhood B-ALL. B-ALL cell lines and precursor cells from bone marrow (BM) and cerebrospinal fluid (CSF) of B-ALL patients indeed overexpressed cortactin. In CXCL12-induced transendothelial migration assays, transmigrated B-ALL cells had highest cortactin expression. In xenotransplantation models, only cortactinen_US
dc.language.isoenen_US
dc.publisherNature publishing groupen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHigh cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
refterms.dateFOA2019-01-04T14:15:02Z
dc.source.journaltitleLeukemia


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