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dc.contributor.authorBruns, Hilke
dc.contributor.authorZiesche, Lisa
dc.contributor.authorTaniwal, Nargis Khakin
dc.contributor.authorWolter, Laura
dc.contributor.authorBrinkhoff, Thorsten
dc.contributor.authorHerrmann, Jennifer
dc.contributor.authorMüller, Rolf
dc.contributor.authorSchulz, Stefan
dc.identifier.citationBeilstein J Org Chem. 2018 Dec 3;14:2964-2973. doi: 10.3762/bjoc.14.276. eCollection 2018.en_US
dc.description.abstractThe human gut microbiome matures towards the adult composition during the first years of life and is implicated in early immune development. Here, we investigate the effects of microbial genomic diversity on gut microbiome development using integrated early childhood data sets collected in the DIABIMMUNE study in Finland, Estonia and Russian Karelia. We show that gut microbial diversity is associated with household location and linear growth of children. Single nucleotide polymorphism- and metagenomic assembly-based strain tracking revealed large and highly dynamic microbial pangenomes, especially in the genus Bacteroides, in which we identified evidence of variability deriving from Bacteroides-targeting bacteriophages. Our analyses revealed functional consequences of strain diversity; only 10% of Finnish infants harboured Bifidobacterium longum subsp. infantis, a subspecies specialized in human milk metabolism, whereas Russian infants commonly maintained a probiotic Bifidobacterium bifidum strain in infancy. Groups of bacteria contributing to diverse, characterized metabolic pathways converged to highly subject-specific configurations over the first two years of life. This longitudinal study extends the current view of early gut microbial community assembly based on strain-level genomic variation.en_US
dc.publisherBeilstein Instituten_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.subject2-aminobutyric aciden_US
dc.subjectamino acid derivativesen_US
dc.subjecthomoserine lactonesen_US
dc.subjectnatural productsen_US
dc.subjectquorum sensingen_US
dc.titleN-Acylated amino acid methyl esters from marine group bacteria.en_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.source.journaltitleBeilstein journal of organic chemistry

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Attribution-NonCommercial-ShareAlike 4.0 International
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