The Effect of Cytochalasans on the Actin Cytoskeleton of Eukaryotic Cells and Preliminary Structure⁻Activity Relationships.
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Authors
Kretz, RobinWendt, Lucile
Wongkanoun, Sarunyou
Luangsa-Ard, J Jennifer
Surup, Frank
Helaly, Soleiman E

Noumeur, Sara R
Stadler, Marc

Stradal, Theresia E B

Issue Date
2019-02-19
Metadata
Show full item recordAbstract
In our ongoing search for new bioactive fungal metabolites, two new cytochalasans were isolated from stromata of the hypoxylaceous ascomycete Hypoxylon fragiforme. Their structures were elucidated via high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. Together with 23 additional cytochalasans isolated from ascomata and mycelial cultures of different Ascomycota, they were tested on their ability to disrupt the actin cytoskeleton of mammal cells in a preliminary structure–activity relationship study. Out of all structural features, the presence of hydroxyl group at the C7 and C18 residues, as well as their stereochemistry, were determined as important factors affecting the potential to disrupt the actin cytoskeleton. Moreover, reversibility of the actin disrupting effects was tested, revealing no direct correlations between potency and reversibility in the tested compound group. Since the diverse bioactivity of cytochalasans is interesting for various applications in eukaryotes, the exact effect on eukaryotic cells will need to be determined, e.g., by follow-up studies involving medicinal chemistry and by inclusion of additional natural cytochalasans. The results are also discussed in relation to previous studies in the literature, including a recent report on the anti-Biofilm activities of essentially the same panel of compounds against the pathogenic bacterium, Staphylococcus aureus. View Full-TextCitation
Biomolecules. 2019 Feb 19;9(2). pii: biom9020073. doi: 10.3390/biom9020073Affiliation
HZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.Publisher
MPDIJournal
BiomoleculesPubMed ID
30791504Type
ArticleLanguage
enISSN
2218-273Xae974a485f413a2113503eed53cd6c53
10.3390/biom9020073
Scopus Count
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