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dc.contributor.authorKretz, Robin
dc.contributor.authorWendt, Lucile
dc.contributor.authorWongkanoun, Sarunyou
dc.contributor.authorLuangsa-Ard, J Jennifer
dc.contributor.authorSurup, Frank
dc.contributor.authorHelaly, Soleiman E
dc.contributor.authorNoumeur, Sara R
dc.contributor.authorStadler, Marc
dc.contributor.authorStradal, Theresia E B
dc.date.accessioned2019-03-06T15:27:16Z
dc.date.available2019-03-06T15:27:16Z
dc.date.issued2019-02-19
dc.identifier.citationBiomolecules. 2019 Feb 19;9(2). pii: biom9020073. doi: 10.3390/biom9020073en_US
dc.identifier.issn2218-273X
dc.identifier.pmid30791504
dc.identifier.doi10.3390/biom9020073
dc.identifier.urihttp://hdl.handle.net/10033/621716
dc.description.abstractIn our ongoing search for new bioactive fungal metabolites, two new cytochalasans were isolated from stromata of the hypoxylaceous ascomycete Hypoxylon fragiforme. Their structures were elucidated via high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. Together with 23 additional cytochalasans isolated from ascomata and mycelial cultures of different Ascomycota, they were tested on their ability to disrupt the actin cytoskeleton of mammal cells in a preliminary structure–activity relationship study. Out of all structural features, the presence of hydroxyl group at the C7 and C18 residues, as well as their stereochemistry, were determined as important factors affecting the potential to disrupt the actin cytoskeleton. Moreover, reversibility of the actin disrupting effects was tested, revealing no direct correlations between potency and reversibility in the tested compound group. Since the diverse bioactivity of cytochalasans is interesting for various applications in eukaryotes, the exact effect on eukaryotic cells will need to be determined, e.g., by follow-up studies involving medicinal chemistry and by inclusion of additional natural cytochalasans. The results are also discussed in relation to previous studies in the literature, including a recent report on the anti-Biofilm activities of essentially the same panel of compounds against the pathogenic bacterium, Staphylococcus aureus. View Full-Texten_US
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAscomycotaen_US
dc.subjectXylarialesen_US
dc.subjectactin cytoskeletonen_US
dc.subjectchromatographyen_US
dc.subjectsecondary metabolitesen_US
dc.subjectstructure elucidationen_US
dc.titleThe Effect of Cytochalasans on the Actin Cytoskeleton of Eukaryotic Cells and Preliminary Structure⁻Activity Relationships.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.en_US
dc.identifier.journalBiomoleculesen_US
refterms.dateFOA2019-03-06T15:27:16Z
dc.source.journaltitleBiomolecules


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