Prevotella copri in individuals at risk for rheumatoid arthritis.
dc.contributor.author | Alpizar-Rodriguez, Deshire | |
dc.contributor.author | Lesker, Till Robin | |
dc.contributor.author | Gronow, Achim | |
dc.contributor.author | Gilbert, Benoît | |
dc.contributor.author | Raemy, Elena | |
dc.contributor.author | Lamacchia, Celine | |
dc.contributor.author | Gabay, Cem | |
dc.contributor.author | Finckh, Axel | |
dc.contributor.author | Strowig, Till | |
dc.date.accessioned | 2019-03-15T09:18:22Z | |
dc.date.available | 2019-03-15T09:18:22Z | |
dc.date.issued | 2019-02-13 | |
dc.identifier.citation | Ann Rheum Dis. 2019 Feb 13. pii: annrheumdis-2018-214514. doi: 10.1136/annrheumdis-2018-214514. | en_US |
dc.identifier.issn | 1468-2060 | |
dc.identifier.pmid | 30760471 | |
dc.identifier.doi | 10.1136/annrheumdis-2018-214514 | |
dc.identifier.uri | http://hdl.handle.net/10033/621722 | |
dc.description.abstract | Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of In an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures. A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA. | en_US |
dc.publisher | BMJ-Journals | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | epidemiology of ra | en_US |
dc.subject | microbiome | en_US |
dc.subject | pre-clinical stages of ra | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.title | Prevotella copri in individuals at risk for rheumatoid arthritis. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany. | en_US |
dc.identifier.journal | Annals of the rheumatic diseases | en_US |
refterms.dateFOA | 2019-03-15T09:18:22Z | |
dc.source.journaltitle | Annals of the rheumatic diseases |