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dc.contributor.authorAlpizar-Rodriguez, Deshire
dc.contributor.authorLesker, Till Robin
dc.contributor.authorGronow, Achim
dc.contributor.authorGilbert, Benoît
dc.contributor.authorRaemy, Elena
dc.contributor.authorLamacchia, Celine
dc.contributor.authorGabay, Cem
dc.contributor.authorFinckh, Axel
dc.contributor.authorStrowig, Till
dc.date.accessioned2019-03-15T09:18:22Z
dc.date.available2019-03-15T09:18:22Z
dc.date.issued2019-02-13
dc.identifier.citationAnn Rheum Dis. 2019 Feb 13. pii: annrheumdis-2018-214514. doi: 10.1136/annrheumdis-2018-214514.en_US
dc.identifier.issn1468-2060
dc.identifier.pmid30760471
dc.identifier.doi10.1136/annrheumdis-2018-214514
dc.identifier.urihttp://hdl.handle.net/10033/621722
dc.description.abstractRheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of In an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures. A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA.en_US
dc.publisherBMJ-Journalsen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectepidemiology of raen_US
dc.subjectmicrobiomeen_US
dc.subjectpre-clinical stages of raen_US
dc.subjectrheumatoid arthritisen_US
dc.titlePrevotella copri in individuals at risk for rheumatoid arthritis.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.en_US
dc.identifier.journalAnnals of the rheumatic diseasesen_US
refterms.dateFOA2019-03-15T09:18:22Z
dc.source.journaltitleAnnals of the rheumatic diseases


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